Tyrant® Cortisol Reducing Hardening Agent

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Calcium D-Glucarate

Calcium D-Glucarate is a powerful inhibitor of β-glucuronidase, which enhances the detoxification pathways of the body. Additionally, calcium d-glucarate has shown to be particularly effective in reducing estrogen and lipid levels. In fact some research notes that supplementation with this estrogen-lowering compound can reduce serum levels of estrogen by as much as 23%![1,2]

Green Tea Extract

Highly touted for its numerous health benefits, particularly in regards to cardiovascular health, green tea is included for its fat loss benefits. Green tea leaves are rich in several polyphenols and catechins, most notably EGCG. Countless studies have shown that green tea catechins increase energy expenditure and fat loss.[3,4] Some research even notes green tea can improve exercise endurance, meaning you’ll burn more calories during your workouts leading to even faster fat loss![5]


Naturally-occurring in the human brain, phosphatidylserine is a fat soluble amino acid derivative known for its ability to improve cognition, mental processing, and memory.[6,7] But it’s also a valuable cortisol lowering agent, too.

Phosphatidylserine reduces Adrenocorticotropic hormone (ACTH), the hormone primarily responsible for cortisol production in the body.[8] Lowering ACTH effectively results in lower cortisol production in the body, helping you stay less stressed and indirectly boosting anabolic hormones (i.e. testosterone), since chronically elevated cortisol levels can blunt testosterone production.

Diindolylmethane (DIM)

Found in all kinds of cruciferous vegetables like broccoli, cauliflower, and cabbage, diindolylmethane (DIM) is an potent aromatase inhibitor and estrogen blocker. DIM shifts estrogen metabolism in the body to work for you instead of against you. In particular, DIM stimulates Phase I enzymes which activates AhR in order to get more “good estrogen”, like 2-hydroxyestrone and less “bad estrogens”, such as 4-hydroxy and 16-hydroxy.[9,10,11]

Estrogen is not bad, but excessive estrogen can lead to fat gain, cause difficulty losing fat, water retention, mood swings, cravings and other deleterious effects. Cortisol like estrogen is not inherently bad, but excessive cortisol— otherwise known as the “stress hormone”, can slow down fat loss and even lead to the body storing fat in “problem areas” like the hips and butt in women and stomach and lower back in men. And with the stresses of life, cortisol can get out of control!

We don’t want to eliminate estrogen since it is needed for muscle growth and fat loss. Rather than eliminating all estrogen, we want to control estrogen in your favor! MTS Nutrition TYRANT™ can increase the amount of “good” estrogens (2-hydroxy) and decreases the amount of “bad” estrogens (4-hydroxy and 16-hydroxy). This means optimizing muscle growth and fat loss by producing more “good” estrogens while decreasing the risks of elevated “bad” estrogen levels. Cortisol is called the “stress hormone” because it is released in response to stress and anxiety. When released at a normal level, cortisol helps restore homeostasis after stressful events. But when too much cortisol is released or cortisol levels are elevated for too long, negative effects arise. Excessive cortisol levels can lead to suppression of the immune system, excessive protein breakdown, and the accumulation of abdominal fat. We don’t want to get rid of cortisol since we need it, we want to control it.

Here is a quick summary of the effects of these ingredients:
  • DIM positively shifts estrogen metabolism to produce more good estrogens and less bad estrogens.
  • Calcium D Glucarate increases the elimination of cancer-promoting toxins and estrogens.
  • Phosphatidylserine not only will improve brain functioning but will also help control cortisol levels.
  • Green tea improves overall health and promotes fat loss.

MTS Nutrition Tyrant - Hardening Agent
Rating : 5/5 - 28 Reviews.
$34.99 In Stock

1. Walaszek Z, et al; Dietary glucarate as anti-promoter of 7,12-dimethylbenz{a}anthracene-induced mammary tumorigenesis . Carcinogenesis. (1986)

2. Heerdt AS, Young CW, Borgen PI; Calcium glucarate as a chemopreventive agent in breast cancer . Isr J Med Sci. (1995)

3. Nagao T, et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. (2005)

4. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond). (2009)

5. Ota N, Soga S, Shimotoyodome A. Daily consumption of tea catechins improves aerobic capacity in healthy male adults: a randomized double-blind, placebo-controlled, crossover trial. Biosci Biotechnol Biochem. (2016)

6. Parker, A; The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise.; Department of Kinesiology, Angelo State University; 2011

7. Vakhapova, V; Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial.; Neurology Department, Tel-Aviv Sourasky Medical Center; 2010

8. Monteleone P, et al; Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men . Eur J Clin Pharmacol. (1992)

9. Sanderson JT, Slobbe L, Lansbergen GW, Safe S, van den Berg M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2001;61(1):40-48.

10. Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol. 1993;45(5):1129-1136

11. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-hydroxyestrone: the “good” estrogen. J Endocrinol. 1996;150 Suppl:S259-65.

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Chuck C.
United States

May 23rd, 2024

I have noticed since taking Tyrant that I have lost a solid inch around my waist but more importantly, the definition that I am seeing with my abs is noticeable. I have taken Tyrant for 2 months and my workout routine has not changed all that much. I do a lot of MRT / Superset training and I am excited to see what the results look like after a few more months.

Greg J.
United States United States


Tyrant is a true to its name supplement. I noticed a difference after one week of taking it and losing body fat.

Christian A.
United States United States


So far so good! Recently had my hormones checked and my doctor recommended these key ingredients and coincidentally bought this prior to my appointment! So I know I’m getting the best!

Ryan D.
United States United States

Solid Product to Accent Everything Else

This is a staple product for me that I use in higher stress times. I notice deeper, more restful sleep and less soreness over time when I’m utilizing it. It doesn’t replace a sound nutrition and exercise regiment but it will provide that extra 3-5% to boost results.

Garrett R.
United States United States


tyrant has helped me get off of AI’s for my trt treatment. Highly recommend for someone wanting to balance your hormones better.

Nutrition Info

Warning Concerning California Residents: This product may contain chemicals known to the State of California to cause cancer and birth defects or reproductive harm.