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Yohimbine HCL - 90 caps

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MTS Nutrition Yohimbine HCL - Targeted Fat Loss Supplement


A lot of this information was learned from IFPA Pro Tommy Jeffers who was mentored by Lyle McDonald.

Yohimbe is harvested from trees grown in Africa and is used and sold as a supplement for fat loss and male sexuality. Yohimbine is a component of yohimbe and is the main alkaloid (and main active component) within yohimbe that produces the desired effects such as fat loss and male function (more shakin’ and bakin’).

We want the Yohimbine HCl—the ACTIVE EXTRACT-- not yohimbe bark which tends to not be accurately dosed. Thus, DO NOT BUY the bark, get the HCl version, as we make at MTS Nutrition. That way, we know what dose we are getting and can control the amount carefully, thus minimizing any side effects and maximizing results.


Yohimbine works on the alpha receptors. Alpha receptors inhibit fat breakdown, so wherever they are abundant, you have a harder time losing fat in that area. For example, they are in high concentration in men’s lower back and abs and in women’s hips and thighs. Yohimbine HCl acts as an alpha receptor blocker. Since alpha receptors inhibit fat breakdown, and Yohimbine HCl inhibits alpha receptors, the net result is that you get an INCREASE in fat breakdown. Thus, you get a significant increase in fat breakdown directly from an area that normally is the hardest place to lose it from. This is one reason why trainers like myself ALWAYS have my clients use this precontest!


Based on the studies we have examined, I recommend working up to 0.2mg/Kg of bodyweight. So that means a 220lb bodybuilder (divide by 2.2 to get Kg) is 100Kg and would work up to a dose of 20mg of Yohimbine HCl, or eight capsules of MTS Nutrition Yohimbine HCl. I would typically start this person at one capsule and work up towards the full dose each consecutive session the person had no undesirable side effects.

As I was discussing with Joe Daniels of Swing This Kettlebells, Yohimbine HCl's effects work the best in the absence of insulin, and its effects start to diminish the more insulin is present. But this doesn’t mean that you cannot eat carbs! Insulin will usually be under control on a lower carb diet, like most trainers will put you on. Obviously, cardio first thing in the morning is a good time (with a scoop of MTS Nutrition Whey in your belly) and even post workout. What you can do is take the Yohimbine HCl DURING your weight training workout 15-20 minutes before you are done. Then, hop on the cardio post weights and BAM—FAT BLAST!


Some studies on YHCl we used to extrapolate this data:

1) Starke K, Trendelenburg AU, Limberger N. Presynaptic a 2-adrenoceptors: subtype determination. In: "Adrenoceptors: Structure, Function, and Pharmacology", Ruffolo, RR ed. Harwood Academic Publishers. 1995:99-108.
2) Byland, DB. Subtypes of a 1- and a 2-adrenergic receptors. FASEB J 1992; 6:832-839.
3) Heible JP, Ruffolo RR, Starke K. Identification, characterization and subclassification of a 2-adrenoceptors: an overview. In: "a 2-Adrenergic Receptors: Structure, Function and Therapeutic Implications". Lanier SM, Limbird LE eds. Harwood Academic Press. 1997:1-18.
4) Raiteri M, Bonanno G, Maura G, et al. Subclassification of release-regulating a 2-autorecptors in human breain cortex. Br J Pharmacol 1992; 107:1146-1151.
5) Piascik MT, Smith MS, Edelmann SE, et al. a 2 and a 1-Adrenergic receptors in the regulation of peripheral vascular function. In: "a 2-Adrenergic Receptors: Structure, Function and Therapeutic Implications". Lanier SM and Limbird LE eds. Harwood Academic Publishers. 1997:171-178.
6) Trendelenburg AU, Limberger N, Rump LC. a 2-Adrenergic receptors of the a 2C subtype mediate inhibition of norepinephrine release in human kidney cortex. Mol Pharmacol 1994; 415:M68-M76.
7) Galitzky J, Larrouy D, Berlan M, Lafontan M. New tools for human fat cell alpha2A-adrenoceptor characterization. Identification on membranes and on intact cells using the agonist [3H]RX821002. J Pharmacol Exp Ther 1990; 252:312-319.
8) Lafontan M, Berlan M. Fat cell alpha2-adrenoceptors: the regulation of fat cell function and lipolysis. Endocr Rev 1995 Dec, 16(6):716-738.
9) Arner P, Kriegholm E, et al. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clinical Invest 1990; 85:893-898.
10) Maurige P, J Galitzky, M Berlan, M Lafontan. Heterogeneous distribution of beta and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur J Clin Invest 1987; 17:156-165.
11) Lafontan M, et al. Adrenergic regulation of adipocyte metabolism. Hum Reprod 1997 Oct; 12 Suppl 1:6-20.
12) Gether U, Lin S, Kobilka BK. Delineating ligand-specific structural changes in adrenergic receptors by use of fluorescence spectroscopy. In: "a 2-Adrenergic Receptors: Structure, Function and Therapeutic Implications". Lanier SM and Limbird LE eds. 1997. Harwood Academic Publishers. 1997: 31-42.
13) Hodgetts V, Coppack S, Frayn KN, Hockaday TDR. Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. J Appl Phys 1991; 71:445-451.
14) Millet L, Barbe M, Lafontan M, Berlan M, Galitzky J. Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue. J Appl Physiol 1998; 85(1):181-188.
15) Ruffolo RR, Bondinell W, Hieble JP. a - and b -Adrenoceptors: From the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem 1995; 38(19):3415-3444.
16) Arner P, Bolinder J. Microdialysis of adipose tissue. J Int Med 1991; 230:381-386.
17) Frayn KN, Fielding BA, Summers LKM. Investigation of human adipose tissue metabolism in vivo. J Endo 1997; 155:187-189.
18) Willette RN, Hieble JP, Sauermelch CF. The role of the alpha adrenoceptor subtypes in sympathetic control of the acralcutaneous microcirculation. J Pharmacol Exp Ther 1991; 256:599-605.
19) Borbujo J, Garcia-Villalon AL, Balle J, et al. Postjunctional alpha-1 and alpha-2 adrenoceptors in human skin arteries. An in vitro study. J Pharmacol Exp Ther 1989; 249:284-287.
20) Galitzky J, Lafontan M, Nordenstrom J, Arner P. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest 1993; 91:1997-2003.
21) Horn PT, Kohli JD, Listinsky JJ, Goldberg LI. Regional variation in the alpha-adrenergic receptors in the canine resistance vessels. Nauyn-Schmiedeberg’s Arch Pharmacol 1982; 318:166-172.
22) Flavahan NA, Cooke JP, Shepherd JT, Vanhoutte PM. Human postjunctional alpha-1 and alpha-2 adrenoceptors: differential distribution in arteries of the limbs. J Pharmacol Exp Ther 1987; 24:361-365.
23) Glusa E, Markwardt F. Characterization of postjunctional alpha-adrenoceptors in isolated human femoral veins and arteries. Nauyn-Schmiedeberg’s Arch Pharmacol 1983; 323:101-105.
24) Enoksson S, Nordenstrom J, Bolinder J, Arner P. Influence of local blood flow on glycerol levels in human adipose tissue. Int J Obesity 1995; 19:350-354.
25) Kovach AGB, Kovach E, Sandor P, et al. Metabolic responses to localized ischemia in adipose tissue. J Surg Res 1976; 20:37-44.
26) Barbe P, Galitzky J, Riviere D, Senard JM, et al. Effects of physiological and pharmaceutical variation of sympathetic nervous system on plasma non-esterified fatty acid concentrations in man. Br J Pharm 1993; 36:25-30.
27) Harmelen VV, Lonnqvist F, Thorne A, et al. Noradrenaline-induced lipolysis in isolated mesenteric, omental and subcutaneous adipocytes from obese subjects. Int J Obesity 1997; 21:972-979.
28) Arner P. Regulation of lipolysis in fat cells. Diab Rev 1996; 4:450-463.
29) Bjorntorp P. Obesity and the adipocyte. Neuroendocrine factors in obesity. J Endocrin 1997; 155:193-195.
30) Abate N, Garg A. Heterogeneity in adipose tissue metabolism: causes, implications, and management of regional adiposity. Prog Lipid Res 1995; 34:53-70.
31) Maurige P, et al. Regional difference in adipose tissue lipolysis from lean and obese women: existence of postreceptor alterations. Am J Physiol 1995 Aug; 269(2 pt 1): E341-E350.
32) Hellstrom L, Blaak E, Hagstrom-Toft E. Gender differences in adrenergic regulation of lipid mobilization during exercise. Int J Sports Med 1996; 17:439-447.
33) Goldberg MR Robertson D. Yohimbine: a pharmacological probe for study of the a 2-adrenoceptor. Pharmacol Rev 1983;35:143-180.
34) Berlan M, Galitzky J, Riviere D, et al. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women. Int J Obesity 1991; 15:305-315.
35) Galitzky J, Taouis M, Berlan M, Riviere D, et al. a 2-Antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect oral yohimbine in healthy male volunteers. Eur J Clin Invest 1988; 18:587-594.
36) Galitzky j, Riviere D, Tran MA, Montastruc JL, Berlan M. Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers. Eur J Clin Pharmacol 1990; 39:447-451.
37) Kuchio C, Jonderdo K, Piskorska D. Does yohimbine act as a slimming drug? Isr J Med Sci 1991; 27:550-556.
38) Zahorska-Markiewiz B, Kuchio, Piskorska D. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metabol Res. 1986; 18:693-697.
39) Murburg MM, Villacres EC, Ko BN, Veith RC. Effects of yohimbine on human sympathetic nervous system function. J Clin Endocrin Metab 1991; 73:861-865.
40) Sax L. Yohimbine does not affect fat distribution in men. Int J Obesity 1991; 3:261-280.
41) Bulow J. Adipose tissue blood flow during exercise. Dan Med Bull 1983; 30:85-100.
42) Bulow J, Madsen J. Regulation of fatty acid mobilization from adipose tissue during exercise. Scand J Sports Sci 1986; 8:19-26.
43) Bulow J, Madsen J, Astrup A, Christensen NJ. Vasoconstrictor effect of high FFA/albumin ratios in adipose tissue in vivo. Acta Physiol Scand 1985; 125:661-667.
44) Berlan M, Montastruc JL, Lafontan M. Pharmacological prospects for a 2-adrenoceptor antagonist therapy. TiPS Rev 1992; 13:277-282.
45) Montastruc P, Belan M, Monstastruc JL. Effect of yohimbine on submaxiallary salivation in dogs. Br. J Pharmac 1989; 98:101-104.
46) Chatelut E, Rispail Y, Berlan M, Montastruc JL. Yohimbine increases human salivary secretion. Br J Clin Pharmac 1989; 366-368.)
47) Fiaramonti J, Berlan M, Fargeas MJ, Bueno L. Yohimbine stimulates colonic motility through a central action in conscious dogs. J Gastrointes Mot 1992; 4:137-141.
48) Charney DS, Heninger GR, Breier A. Noradrenergic function in panic anxiety. Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder. Arch Gen Psychiatry 1984; 41:751-763.
49) Murburg MM, Villacres EC, Ko BN, Veith RC. Effects of yohimbine on human sympathetic nervous system function. J Clin Endocrin Metab 1991; 73:861-865.
50) Grunhaus L, Tiongco D, Zelnik T, Flegel P, et al. Intravenous yohimbine. Selective enhancer of norepinephrine and cortisol secretion and systolic blood pressure in humans. Clin Neuropharmacol 1989; 12:106-114.
51) Henninger GR, Charney DS, Price LH. a 2-Adrenergic receptor sensitivity in depression. The plasma MHPG, behavioral and cardiovascular responses to yohimbine. Arc Gen Psychiatry 1988; 45:718-726.
52) McDougle CJ, Krystal JH, Price LH, Heninger GR, et al. Noradrenergic response to acute ethanol administration in healthy subjects: comparisons with intravenous yohimbine. Psychopharmacol 1995; 118:127-135.
53) Betz, JM, White KD. Gas chromatographic determination of yohimbine in commercial yohimbine products. J AOAC Int. 1995; 78:1189-1194.
54) Benedek IH, Blouin RA, McNamara PJ. Serum protein binding and the role of increased alpha1-acid glycoprotein in moderately obese subjects. Br J Clin Pharmacol 1984; 18:941-946.
55) Guthrie SK, Hariharan M, Grunhaus LJ. Yohimbine bioavailability in humans. Eur J Clin Pharmacol 1990; 39:409-411.
56) Hedner T, Edgar B, Edvinsson L, Hedner J, et al. Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers. Eur J Clin Pharmacol 1992; 43:651-656.
57) Owen JA, Hakatsu SL, Fenemore J, Condra M, et al. The pharmacokinetics of yohimbine in man. Eur J Clin Pharmacol 1987; 32:577-582.
58) Le Verge R, Le Corre P, Chevanne F. Determination of yohimbine and its two hydroxylated metabolites in humans by high-performance liquid chromatography and mass spectral analysis. J Chromatog 1992; 574:283-292.
59) Brannan T, Martinez-Tica J, Yahr MD. Effect of yohimbine on brain monoamines: an in vivo study. J Neural Transm 1991; 3:81-87.
60) Hubbard JW, Pfister SL, Beidinger Am, Herzig TC, et al. The pharmacokinetic properties of yohimbine in the conscious rat. Naunyn-Schmiedeberg’s Arch Pharmacol 1988; 337:583-587.
5.0 / 5.0
79 Reviews
5 Stars
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1 Stars
4.8 / 5
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Delivery Speed
4.9 / 5
Great product
I really like the product and the gift that comes with it.
I always recommend to friends and family.
And I will be back for more!
September 4, 2015
Love this stuff already losing some lower belly fat. Which has been hard for me to lose after being paralyzed from waste down. Not able to power lift anymore. So just trying to lean. I would recommend this to anyone. Im currently stacking with barracuda and ruckus and loving it
Before paralyzed
During recovery
December 20, 2016
Age: 25-44
10 months ago
One of the most effective fat burners on the market.
In my last 6 weeks of prep, I swear by Yohimbine HCL and caffeine (I use Drop Factor) to help get the last bits of stubborn fat off my for my figure competitions. It can be a bit intense if you've never used it before, but if you build up gradually to the clinical dose, you will definitely see results.
September 4, 2015
5 / 5
5 / 5
5 / 5
Delivery Speed
5 / 5
Fair price with a good quality yohimbine. You'll sweat especially if you stack it with drop factor.
May 5, 2017
Age: 25-44
6 months ago
Fitness Goal:
Fat Loss
5 / 5
5 / 5
5 / 5
Delivery Speed
5 / 5
Make sure you read the instructions and work your way up to the max dose. Once your body gets use to the delivery of the capsules this product is great as a stand alone or stacked with drop factor.
October 13, 2017
Age: 25-44
7 months ago
Fitness Goal:
5 / 5
5 / 5
5 / 5
Delivery Speed
5 / 5
Exactly what you want
You get exactly what you want with this. MTS always gives you quality products
October 3, 2017
Age: 15-24
1 month ago
Fitness Goal:
Build Muscle
Work well give it three
Work well give it three week to really kickin
September 4, 2015
The staff is great, I
The staff is great, I called because a product was out of stock and they were very helpful and promoted another similar product by sharing self experiences. They encouraged me to try it and I am glad I did. Not only are the products great, the shipping is always fast and I love the fact the staff are enthusiastic the products they use and are able to provide feedback and truly show they care about customer satisfaction.
July 27, 2015
Great little aid to fat loss
Yohimbine is just one small part of my fat loss goals, but it helps for sure.
September 4, 2015
5 / 5
5 / 5
5 / 5
Delivery Speed
5 / 5
My favorite!!
October 3, 2017
Age: 25-44
1 month ago
Fitness Goal:
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 27 questions Browse 27 questions and 51 answers
should i cycle this off or will i be alright buying and taking it again after finishing on a bottle?
josue g on Feb 1, 2016
Yohimbine HCL - 90 caps
Yohimbine HCL - 90 caps
Drop Factor 120 Capsules
Drop Factor 120 Capsules
BEST ANSWER: Eventually your body will build up a tolerance to these products and they can be less effective over time, therefore, I would suggest cycling off for 1-2 weeks between bottles.
My wife is looking for a supplement like this. Can women take this supplement?
A shopper on Jan 25, 2016
BEST ANSWER: Yes, women can take this. I take it first thing in the morning before doing a cardio session and I definitely feel like I have more energy. I'm sweating like crazy by the time I finish my session.
Can I take this with MTS Drop Factor? Or will this be too much? ( I don't take fat burners, pre work out or coffee so my body will not be use to caffeine or the jitters"
Danzel D on Aug 18, 2015
BEST ANSWER: I currently take it with Pre Gro and my body handles it well. No jitters to speak of. But without a doubt elevates the heart rate. I take as directed and I believe this has been the best fat loss supplements I've taken. I have never sweat more off of any other pill. Yohimbine is a solid supplement and for the price can't be beat!
I weight 150 pounds how many should I take?
Jesenia Z on Sep 12, 2015
BEST ANSWER: Always start easy and asses your tolerance. I would start 1 capsule, once a day for at least three to five days. Then 1 capsule twice a day for at least a week. Move up to 2 capsules on the morning and 1 later in the day. At 150 pounds I don't know that I would go more than that. I know Marc has also done You Yube videos on proper Yomibe dosing and gone over when to take when stacking other Fat Burning products.
Can you use this without using mts drop factor? Is it still going to be effective?
A shopper on May 16, 2016
BEST ANSWER: Yep. MTS Yohimbine is a great inexpensive yet very effective standalone product. I recommend to take the majority of your daily dose pre-cardio. Also as you may know, MTS Machine Fuel (BCAA's) are great anytime but especially while dieting or in a calorie deficit. Enjoy!
I weigh 205 pounds how many capsules should I take?
A shopper on Nov 12, 2015
BEST ANSWER: 18 to 20mg approx 6 or 7 capsules. I'm 243 and i take 10 : 5 before morning cardio and another 5 before evening workouts dosage is based on kg of body so hope i saved you some time converting the mg/lb hope this helps
can you open the capsules ??
A shopper on Sep 26, 2015
BEST ANSWER: Absolutely. I twist them open them and add the powder to my MTS Drop Factor before fasted cardio. Hope this helps.
I weigh 162 LBS what is the dosage I should take?
A shopper on Jul 4, 2017
BEST ANSWER: Recommended dosage for yohimbine hcl
Is .2 mg per kilogram of weight. Since you're 162 that puts you about 73kg which means you'd take a total dosage per day of 14.6 mg. Since the capsules are 2.5mg each that means 5-6 capsules per day. I recommend splitting it into two dosages, one of them pre cardio. If you do cardio post workout, take a
dose about 20 minutes before you start. Remember yohimbine only works in low low insulin levels so at LEAST 30-45 minutes before or after any food has hit the system. Works best with fasted cardio and post-workout cardio. Done right, stuff works like magic for trouble spots, particularly my lower back and abs. Keep it consistent and you'll see awesome results!
Is Yohimbine considered a banned substance as ler WADA regulations? I can't find it in the 2017 version but I have heard it was banned. I am competiting in tested bikini and they run pee tests on winners. Thanks
A shopper on Apr 30, 2017
BEST ANSWER: I am not seeing it on the banned list but please check with the organization you are competing in just to be 10000% safe!
If I am not doing cardio that day, will Yohimbine till be affective if I just take it before my workout?
A shopper on Aug 26, 2016
BEST ANSWER: Yes, just take it once a day preferably before cardio or exercise
Do I need o do cardio or I can just workout?
A shopper on May 17, 2016
BEST ANSWER: cardio is not required but will benefit you if you are trying to lose weight.
What is the best time to take it if you are working out in evening without ant cardio?
A shopper on May 16, 2016
BEST ANSWER: I personally would not take Yohimbine, in the evening especially if no cardio, the best time to take is in the morning with cardio

This stuff is very potent,
When is best time for me to take this, I'm 195 so that's about 7 pills , do I take 4 morning and 3 night/before working out?
A shopper on Dec 27, 2015
BEST ANSWER: I would split 4 and 3 for morning and pre-cardio BUT 7 at once, if you work up to it, pre cardio...isn't crazy!
Has anyone stacked this product with green tea extract or synephrine?
A shopper on Jun 23, 2017
Yohimbine HCL - 90 caps
Yohimbine HCL - 90 caps
Drop Factor
Drop Factor
BEST ANSWER: I have not but you could, just watch the overall amount of caffeine you're intaking.. Totally my opinion and you can ignore it but if I were you, rather than adding in more supplements you might want to adjust your macro/calorie intake. Or increase activity level. Remember - "nothing works unless you do". Good luck!
Is this product Gluten Free?
Todd G on Jun 17, 2017
Can I take this with Nutrabio Thermofuel? If so, can I take them together or put a couple of hours between them? I'm 309lbs so I would work up to 28mg. I've read that might be a little high. is that correct?
Terry T on Jun 8, 2017
Yohimbine HCL - 90 caps
Yohimbine HCL - 90 caps
NutraBio ThermoFuel V9 for Men 180 Capsules
NutraBio ThermoFuel V9 for Men 180 Capsules
BEST ANSWER: That should be fine, but be sure to SLOWLY work up, one cap at a time
i work at night and get off in the morning but when I get off I got to the gym pretty much immediately. when should I take it?
chriz180 on May 9, 2017
BEST ANSWER: Doesn't matter too much when you take it as long as you take it with two factors.
1. Get the dosage right. .2 mg/kg of body weight, usually spilt in two dosages throughout the day.
2. Take when insulin is lowest in the body eg. when you haven't eaten for at least an hour, preferably more.
So if for example you don cardio after weights you could take the yohimbine to the gym and pop it about 20 minutes before you started your cardio. Then take it some other time of day in between meals.
Can this be stacked with Peak Physicor?
A shopper on May 8, 2017
How long can I take this product? Does it require cycling?
A shopper on Feb 11, 2017
BEST ANSWER: From the data I have seen, this does NOT require cycling
Im not doing any cardio and Im working in evening. What is the best time to take it for maximum effect?
A shopper on May 17, 2016
BEST ANSWER: 20 minutes before cardio
When are you getting more?
A shopper on May 3, 2016
BEST ANSWER: the ethitech yohimbine is the same formula with a different label.
Does YOHIMBINE cause hair loss like other fat burners? Not trying to go bald over a little body fat.
A shopper on Mar 31, 2016
BEST ANSWER: I have not heard of hair loss with yohimbine.
i'm taking CFTS fat burner can I take this to?
bryan k on Nov 10, 2015
BEST ANSWER: Yes, you can stack this with most fat burners.
Is this supplement in stock, and which one should I use for fat burning? This one or the Yohimbine HCL 90ct. - EthiTech Nutrition
A shopper on Jul 31, 2015
BEST ANSWER: Ethitech and MTS yohimbine are the exact same just different labels.
Any idea when this will be back in stock?
Rick L on May 10, 2017
When will this restock?
A shopper on May 10, 2017
Can I take this with my hypoglycemia?
A shopper on Feb 21, 2016


As a dietary supplement consume 1-2 capsules daily or use as directed by a physician or licensed nutritionist. Begin using this product at 1/2 the suggested dose to assess tolerance.


Not for use by persons under 21 years of age. Consult a physician prior to use if you have any medical condition including, but not limited to, strokes, high blood pressure, heart, liver, kidney, or thyroid disease, diabetes, anemia, a family history of these or other medical conditions, or if taking any prescription, OTC, and/or other herbal medications.

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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