Guide to Curcumin - Benefits, Dosage, Side Effects
In today’s world, people are looking more and more into all-natural, holistic remedies to address their daily problems. Whether it be something as simple as eliminating a throbbing headache, easing joint aches and pains, or accelerating recovery from exercise, the all-natural way is the way to go for many individuals.
One of the most popular supplements these days is curcumin. It’s touted as a universal panacea and health support supplement that can improve everything from gut health to joint pain and even cognitive function.
Related - 10 Turmeric Benefits - Remarkably Better Than Prescription Drugs?
But what is it?
Is there any solid backing to the claims and perceived benefits of curcumin, or is it just more holistic hocus pocus you’ve seen advertised before.
Let’s find out!
What is Curcumin?
Curcumin is the primary compound found in turmeric (curcuma longa), a fundamental spice in Indian cooking. Not only is turmeric known for its distinctive flavor, it’s also received a lot of attention recently for its pro-health benefits.
Turmeric contains a collection of compounds known as curcuminoids, and curcumin accounts for approximately 3% of the weight in commercially available curry spice blends.  So, if you were planning to start scarfing down turmeric powders and curry blends by the glass full, you might want to hold off, as they aren’t particularly “rich” in curcumin.
Curcuminoids can also be found in ginger, another pungent spice, as well.  While curcumin is the most well known (and plentiful) of the curcuminoid family, it’s only one of four phytochemicals in the group.
HydroCurc technology in Ambrosia Golden provides 9x more effective absorption than regular turmeric or curcumin extracts. Click here to order.
The other members of the curcuminoid family are:
Benefits of Curcumin
Curcumin is a truly fascinating polyphenol, well-documented for its wealth of anti-inflammatory, anti-oxidant, anti-proliferative and anti-microbial activities. Now let’s take a deeper look at these benefits and see why you should consider adding it to your supplement regimen.
Reduces Joint Pain
Far and away, the most popular use for curcumin is in the treatment of joint aches and pains. The reason curcumin is so prevalently used for improving joint health is due to its strong anti-inflammatory activity in the body.
Curcumin inhibits cyclooxygenase (COX) enzymes similar to the manner in which non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen, function. More specifically, curcumin preferentially inhibits the COX-2 enzyme, as opposed to COX-1.  It is possible to inhibit both COX enzymes (as is the case with NSAIDs), but that can often lead to GI distress, due to stomach ulcers.
Curcumin also inhibits lipoxygenase (LOX), making it more potent and easier/safer on your body. 
Why is this good?
Inhibiting or suppressing the actions of these enzymes, prevent anti-inflammatory molecules from becoming inflammatory ones. The next question on your mind most likely is:
What is Inflammation and Why is Inflammation Bad?
Before we go any further, it’s important to note that inflammation in and of itself is not bad. Inflammation simply refers to the actions of the immune system, the system of the body that protects against illness and infection from all sorts of microscopic “bad guys.”
Inflammation is also part of the muscle recovery and growth process. Basically, any sort of repairing, strengthening, growing, or protecting is related to inflammation. It’s essential and incredibly beneficial in the right amounts. But left unchecked, systemic and chronic inflammation can lead to a host of diseases, including arthritis.
When it comes to inflammation, it’s all about balance. Some is good, too much is bad, and too little is also bad as it opens you up to potential illness from parasites, bacteria, etc.
When discussing inflammation and how it relates to arthritis, it essentially boils down to the fact that your body’s immune system starts attacking its own tissues instead of bacteria, parasites, or viruses, which can cause pain, stiffness, swelling, and joint damage. 
So, back to curcumin and its anti-inflammatory activity...
Curcumin decreases a host of inflammatory markers including various interleukines (IL-1, IL-6, IL-8, IL-10) as well as tumor necrosis factor alpha (TNF-a).  It also can inhibit mast cells and decreases diamine oxidase (DAO), which can elevate histamine (another inflammatory compound) levels. 
In fact, curcumin is such a powerful anti-inflammatory, it’s been shown to be stronger than ibuprofen and aspirin, and has even been compared to prescribed corticosteroids in the treatment of inflammatory diseases. 
Supports Cognitive Function
Curcumin isn’t just good for your joints, it’s also good for your brain, too! It increases levels of docosahexaenoic acid (DHA -- one of the fats found in fish oil), by increasing levels of the enzymes involved in DHA synthesis. The reason this is such a big deal, is that even fish oil supplements typically don’t increase brain levels of DHA. 
But that’s not all, curcumin is also neuroprotective, as shown in various trials where curcumin has:
- Defends against cell death in brain injuries 
- Improves neurological function in patients with brain hemorrhages 
- Inhibits cell death (apoptosis) and neuron loss following spinal cord injury 
- Combats cognitive impairment induced by traumatic brain injury 
- Reduces oxidative damage 
- Normalizes levels of Synapsin I, brain-derived neurotrophic factor (BDNF), and CAMP responsive element binding protein 1 (CREB) 
Other animal models have shown the potent compound can prevent memory loss, restore optimal glutathione (a powerful antioxidant) levels, and return insulin receptor protein levels to normal range. These effects may be due in large part to curcumin’s ability to inhibit glycogen synthase kinase 3 beta (GSK3b) -- an enzyme associated with brain function, mood, and inflammation. 
The Curcumin-Alzheimer’s Connection
Studies using bioavailable curcumin (typically curcumin + piperine) have shown it leads to neurogenesis (creation of new brain cells) and reverses the cognitive decline present in patients with Alzheimer’s. Specifically, curcumin stimulates adult hippocampal and developmental neurogenesis as well as neural plasticity and repair.  It also improves memory and learning in adults via increasing brain-derived neurotrophic factor (BDNF). 
Additionally, curcumin also reduce amyloid plaque and protects against quinolinic acid-induced neurodegeneration (brain cell break down), which is brought on by inflammation and stress. 
Combats Metabolic Syndrome
Metabolic syndrome is a medical condition characterized by a group of health markers including:
- High blood pressure
- High blood sugar
- Excess body fat (especially around the waist)
- Elevated cholesterol or triglyceride levels
When combined, these conditions increase your risk of cardiovascular disease, stroke, and diabetes. More often than not, metabolic syndrome is brought on by an inactive, unhealthy lifestyle, and it’s characterized by chronic inflammation and oxidation in the body. Since curcumin is such a powerful anti-inflammatory and antioxidant, it’s believed that it may be beneficial in combating the tell-tale markers of metabolic syndrome.
And it just so happens to be that research does confirm this line of thinking.
Curcumin reduces blood levels of inflammatory markers while increasing levels of anti-inflammatory ones.  It also reduces lipid levels and blood sugar levels of individuals with metabolic syndrome, and helps weight loss.  Curcumin doesn’t just lower blood sugar levels, in improves muscular insulin resistance and prevents insulin resistance and obesity. 
A recent meta-analysis investigated the effects of bioavailable curcumin on metabolic syndrome, and concluded that it “improves oxidative and inflammatory status.”  Researchers also added, “Curcuminoids could be regarded as natural, safe and effective CRP-lowering agents.”  FYI, CRP stands for C-reactive protein, a key blood marker and hallmark sign of inflammation.
Could curcumin be the crucial ingredient to fighting type 2 diabetes, obesity, and the other assorted metabolic issues plaguing those with metabolic syndrome? That can’t be conclusively determined yet, but these results are incredibly promising, to say the least.
Improves Gut Health
Curcumin can also improve gut health and function by stimulating bile release from the gallbladder.  FYI, the gut is often called “the second” brain of the body.
But that’s not all, curcumin also can help prevent the formation of stomach ulcers by inhibiting pepsin activity and stomach acid secretion. In case you weren’t aware, pepsin is a digestive enzyme that breaks down proteins. 
Reduces Stress & Combats Depression
Prescription antidepressants such as imipramine (Tofranil) protect BDNF stores in the body and promote hippocampal neurogenesis. As we’ve already mentioned, curcumin can have the exact same effects in the body.
Animal models have shown that curcumin elicits antidepressant-like effects and enhances the effects of SSRIs (Selective serotonin reuptake inhibitor) and a recent meta-analysis showed it reduced depressive symptoms in patients.  These actions may due in part to curcumin’s interaction with the 5HT2C receptor, a receptor that binds endogenous serotonin.
Curcumin can also reduce stress levels by lowering cortisol levels and enhancing cortisol sensitivity.  Even in healthy individuals, curcumin was able to improve memory, attention, and mood. 
Curcumin and the Big C - Cancer. It’s a hideous disease that robs millions of people of their lives around the globe. Volumes of research have been conducted to determine what effect, if any, curcumin supplementation can have on cancer and tumor cell growth.
Various trials have shown that curcumin administration reduces new blood vessel growth in tumors and induces programmed cell death in human malignant: 
- Brain cancer (glioblastoma) cells 
- T-cell lymphoma cells 
- Bone cells 
- Oral cancer cells 
- Melanoma cancer cells 
Curcumin’s battle with cancer doesn’t end there though, it’s also toxic to cancer cell mitochondria (the “nuclear reactor” that supplies energy to each cell). 
Curcumin has been used at various doses in the litany of clinical trials and research studies that have been conducted. Typically, individuals looking using a curcumin supplement, or a more comprehensive supplement that includes the compound, find it dosed anywhere between 80-500mg.
Any Side Effects?
Overall, curcumin appears to be relatively free of any serious side effects. Human studies have shown it has been consumed up to 10 grams per day without any side effect.  The only minor symptom that has been mentioned in a handful of studies is minor gastrointestinal upset.
The Problem with Curcumin Supplements
Curcumin seems like pretty incredible stuff, so much so that you’re probably willing to shell out a few bucks on a curcumin supplement and see just how powerful it can be for you. But there’s a problem with nearly all curcumin supplements - it has horrendous bioavailability.
In other words, the curcumin supplement you just purchased is most likely going to be degraded and excreted without you getting any notable or observable benefit from it. You see, curcumin is fat-soluble and hydrophobic, which means in aqueous environments (i.e. your stomach) it’s not really well absorbed.
However, there has been a breakthrough in the land of curcumin supplementation that enhances the bioavailability of the compound tremendously, ensuring you get maximum benefit from this incredibly powerful compound.
HydroCurc - The Best Form of Curcumin?
HydroCurc by HydroCurc™ is a cold water dispersible Curcuma longa extract powder, specifically designed to enhance bioavailability of free curcuminoids. This novel form of curcumin utilizes LipiSperse™ delivery technology, which is a lipid-based delivery system specifically designed to increase the dispersion of crystalline lipophilic (fat-soluble) agents in aqueous environments. Attached a ring of lipids (fats) to curcumin lowers surface tension, thereby improving its ability to adhere to particles.
Plain and simple, HydroCurc allows your body to easily absorb curcumin by improving its ability to dissolve in watery environments. Studies using HydroCurc have found it supplies over 80% active curcuminoids - 9x more effective absorption than regular turmeric or curcumin extracts!
Where to Find HydroCurc?
Ambrosia Golden is one of the first supplements to market using the game-changing form of curcumin. Golden is your daily turmeric supplement that supplies 900mg HydroCurc, delivering 765mg of active curcuminoids to your body. Also included in 100% of the RDA of Vitamin C, for extra antioxidant protection and defense.
References1) Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55(2):126-131. doi:10.1207/s15327914nc5502_2.
2) Zhou H, Beevers CS, Huang S. Targets of curcumin. Current drug targets. 2011;12(3):332-347.
3) Goel A, Boland CR, Chauhan DP. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 2001;172(2):111-118.
4) Rao C V. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007;595:213-226. doi:10.1007/978-0-387-46401-5_9.
5) Julemont F, Dogne J-M, Pirotte B, de Leval X. Recent development in the field of dual COX / 5-LOX inhibitors. Mini Rev Med Chem. 2004;4(6):633-638.
6) Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Therapeutic Advances in Musculoskeletal Disease. 2013;5(2):77-94. doi:10.1177/1759720X12467868.
7) Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009;30(2):85-94. doi:10.1016/j.tips.2008.11.002.
8) Gupta A, Vij G, Sharma S, Tirkey N, Rishi P, Chopra K. Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model. Immunobiology. 2009;214(1):33-39. doi:10.1016/j.imbio.2008.04.003.
9) Suzuki M, Nakamura T, Iyoki S, et al. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull. 2005;28(8):1438-1443.
10) Song W-B, Wang Y-Y, Meng F-S, et al. Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-?B Activation. Bereswill S, ed. PLoS ONE. 2010;5(9):e12969. doi:10.1371/journal.pone.0012969.
11) Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004;23(57):9247-9258. doi:10.1038/sj.onc.1208169.
12) Lal B, Kapoor AK, Asthana OP, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res. 1999;13(4):318-322. doi:10.1002/(SICI)1099-1573(199906)13:4<318::AID-PTR445>3.0.CO;2-7.
13) Gupta SC, Patchva S, Aggarwal BB. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. The AAPS Journal. 2013;15(1):195-218. doi:10.1208/s12248-012-9432-8.
14) Wu A, Noble EE, Tyagi E, Ying Z, Zhuang Y, Gomez-Pinilla F. Curcumin boosts DHA in the brain: implications for the prevention of anxiety disorders. Biochimica et biophysica acta. 2015;1852(5):951-961. doi:10.1016/j.bbadis.2014.12.005.
15) Li W, Suwanwela NC, Patumraj S. Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R. Microvasc Res. 2016;106:117-127. doi:10.1016/j.mvr.2015.12.008.
16) Zhang Z-Y, Jiang M, Fang J, et al. Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood-Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress. Mol Neurobiol. 2017;54(1):1-14. doi:10.1007/s12035-015-9635-y.
17) Lin M-S, Lee Y-H, Chiu W-T, Hung K-S. Curcumin provides neuroprotection after spinal cord injury. J Surg Res. 2011;166(2):280-289. doi:10.1016/j.jss.2009.07.001.
18) Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006;197(2):309-317. doi:10.1016/j.expneurol.2005.09.004.
19) Zhang X, Yin W, Shi X, Li Y. Curcumin activates Wnt/beta-catenin signaling pathway through inhibiting the activity of GSK-3beta in APPswe transfected SY5Y cells. Eur J Pharm Sci. 2011;42(5):540-546. doi:10.1016/j.ejps.2011.02.009.
20) Kim SJ, Son TG, Park HR, et al. Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus. The Journal of Biological Chemistry. 2008;283(21):14497-14505. doi:10.1074/jbc.M708373200.
21) Zhang L, Fang Y, Xu Y, et al. Curcumin Improves Amyloid ß-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway. PLoS One. 2015;10(6):e0131525. https://doi.org/10.1371/journal.pone.0131525.
22) Begum AN, Jones MR, Lim GP, et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease. J Pharmacol Exp Ther. 2008;326(1):196 LP-208.
23) Singh S, Kumar P. Neuroprotective Activity of Curcumin in Combination with Piperine against Quinolinic Acid Induced Neurodegeneration in Rats. Pharmacology. 2016;97(3-4):151-160. doi:10.1159/000443896.
24) Yang H, Xu W, Zhou Z, et al. Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp Clin Endocrinol Diabetes. 2015;123(6):360-367. doi:10.1055/s-0035-1545345.
25) Panahi Y, Hosseini MS, Khalili N, et al. Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial. Nutrition. 2016;32(10):1116-1122. doi:10.1016/j.nut.2016.03.018.
26) Na LX, Yan BL, Jiang S, Cui HL, Li Y, Sun CH. Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes. Biomed Environ Sci. 2014;27(11):902-906. doi:10.3967/bes2014.127.
27) Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur Rev Med Pharmacol Sci. 2015;19(21):4195-4202.
28) Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr. 2015;34(6):1101-1108. doi:10.1016/j.clnu.2014.12.019.
29) Rasyid A, Lelo A. The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. Aliment Pharmacol Ther. 1999;13(2):245-249.
30) Mei X, Xu D, Wang S, Xu S. [Pharmacological researches of curcumin solid dispersions on experimental gastric ulcer]. Zhongguo Zhong Yao Za Zhi. 2009;34(22):2920-2923.
31) Tuorkey M, Karolin K. Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL-6 and enzyme activities. Biomed Environ Sci. 2009;22(6):488-495. doi:10.1016/S0895-3988(10)60006-2.
32) Xu Y, Ku B, Cui L, et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res. 2007;1162:9-18. doi:10.1016/j.brainres.2007.05.071.
33) Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials. Phytother Res. 2016;30(2):175-183. doi:10.1002/ptr.5524.
34) Kulkarni SK, Bhutani MK, Bishnoi M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl). 2008;201(3):435-442. doi:10.1007/s00213-008-1300-y.
35) Xu Y, Ku B, Tie L, et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res. 2006;1122(1):56-64. doi:10.1016/j.brainres.2006.09.009.
36) Cox KHM, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015;29(5):642-651. doi:10.1177/0269881114552744.
37) Shao W, Yu Z, Chiang Y, et al. Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes. Schneider-Stock R, ed. PLoS ONE. 2012;7(1):e28784. doi:10.1371/journal.pone.0028784.
38) Na L-X, Zhang Y-L, Li Y, et al. Curcumin improves insulin resistance in skeletal muscle of rats. Nutr Metab Cardiovasc Dis. 2011;21(7):526-533. doi:10.1016/j.numecd.2009.11.009.
39) Ravindran J, Prasad S, Aggarwal BB. Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively? The AAPS Journal. 2009;11(3):495-510. doi:10.1208/s12248-009-9128-x.
40) SORDILLO LA, SORDILLO PP, HELSON L. Curcumin for the Treatment of Glioblastoma. Anticancer Res . 2015;35(12):6373-6378.
41) Zhang C, Li B, Zhang X, Hazarika P, Aggarwal BB, Duvic M. Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients’ PBMCs: potential role for STAT-3 and NF-kappaB signaling. J Invest Dermatol. 2010;130(8):2110-2119. doi:10.1038/jid.2010.86.
42) Lee DS, Lee MK, Kim JH. Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. Anticancer Res. 2009;29(12):5039-5044.
43) Chakravarti N, Kadara H, Yoon D-J, et al. Differential Inhibition of Protein Translation Machinery by Curcumin in Normal, Immortalized and Malignant Oral Epithelial Cells. Cancer prevention research (Philadelphia, Pa). 2010;3(3):331-338. doi:10.1158/1940-6207.CAPR-09-0076.
44) Lu C, Song E, Hu D-N, et al. Curcumin induces cell death in human uveal melanoma cells through mitochondrial pathway. Curr Eye Res. 2010;35(4):352-360. doi:10.3109/02713680903521944.
45) Jung, K., Lee, J.H., Park, J.W., Moon, S., Cho, Y.S., Choe, Y.S., & Lee, K. (2016). Effects of curcumin on cancer cell mitochondrial function and potential monitoring with 18F-FDG uptake. Oncology Reports, 35, 861-868. https://doi.org/10.3892/or.2015.4460
46) Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23(1A):363-398.
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