Genomyx Origin
Genomyx Origin
 
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7110005M

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Description Supplement Facts
 

Genomyx's NEW Origin | The Evolution of Performance Enhancement


The game changer is what we should have called it. We got tired of seeing the same dodgy proprietary blends with so many ingredients, you could never accurately guess if any of it was going to be enough. The pre workout category is flooded with label flare and the same brodacious claims you hear about that one secret trick to getting six pack abs.

We wanted to bring a product to the market that was built simply around effective ingredients at effective doses. We know the serious athlete doesnít need to be dazzled they just want a product that works. Origin is going to take your training to new heights and push your past your limits like never before. Our more in depth explanation of each ingredient will explain why youíll be loving each workout.
L-Citrulline

This alpha amino acid is going to be a surprisingly awesome add to your preworkout regiment if you havenít already tried it. Some of the more popular products have been using it for some time and thatís because it works. Whatís it work for?

Itís more of a cascade of changes than one direct impact, as is the situation with most ingredients in the complex human physiology. However, it has been studied to an appreciable degree in the field of exercise performance and thereís a lot of supporting evidence. Citrulline at a dose of 3g was found to improve exercise performance in young and healthy men and women (1).

L-Citrulline in the form of Citrulline Malate has been shown to indirectly buffer the potential of the pH drop that happens in skeletal muscle during exercise(2). This would explain its anti-fatigue effects during intense training. Extending the pH balance of skeletal muscle during exercise would help maintain cellular integrity under such intense conditions.

In one study it significantly increased bench press performance till failure and significantly reduce the post workout exercise soreness commonly referenced as DOMS (delayed onset muscle soreness)(3.) This makes it an ideal choice for athletes who are working to the extremes of failure during competition and weight lifters whose post leg day muscle soreness can be incredibly debilitating at times.

Overall you can see why we wanted to use l-citrulline in Origin. Itís not just going to help you get a solid pump and help you warm up effectively, itís actually going to improve performance giving you the edge youíre looking for in your pre workout.
L-Citrulline Overview:

Blunt skeletal muscle pH drop
Reduce post workout soreness
Increased tolerance to fatigue

Trimethylglycine

More simply known as betaine, this ingredient has a lot of potential as an ergogenic aid and youíll see its presence in pre workouts more and more these days. It wasnít found in the rain forest, it was actually first discovered in sugar beets. Itís been used in animals for some time now to produce more favorably body composition and enhance the growing process(4).

While the main mode of action remains up for debate there is plenty of evidence accumulating for betaineís use in the physical culture. Itís been studied in humans quite extensively and carries some awesome benefits for the average athlete. One study observed a significant increase in growth hormone and IGF-1 response to exercise, and a significant decrease in the cortisol response(5). This basically means there is greater potential for muscular hypertrophy and improved recovery from exercise with betaine supplementation.

As cool as that is it has also been shown to enhance squat performance and actually increased the quality of the repetitions performed(6). Enhanced performance is paramount to quality of a pre workout, at least in the eyes of the athlete. Not only will betaine enhance performance but it will help you recover for your next practice out on the track or your next lifting session in the power rack.
Trimethylglycine Overview:

Increase GH, IGF-1 response to training
Reduce cortisol response to training
Improve body composition
Improve power output and quality of exercise

Rhodiola Rosea

If youíve yet to hear the term adaptogen, it typically refers to an herb with a wide array of health promoting effects. They help the body cope with various stressors and typically have been used for some time in foreign medicine. Despite having broad applications most adaptogens tend to aid greatly in specific areas and rhodiolaís field of expertise is anti-fatigue(7).

Rhodiola Rosea has been to show stimulate the actions of norepinephrine, dopamine, and serotonin in the central nervous system. These neurotransmitters are responsible for a variety of things such as mood and energy levels. Itís also been shown to increase the ability of dopamine and serotonin precursors to cross the blood brain barrier(7).

Those specific effects should produce higher energy levels, better overall mood, and general sense of wellbeing. These results have actually been demonstrated in a variety of human studies ranging from doctors working the late shifts to high school students(7).

Rhodiola has been demonstrated to enhance exercise performance with acute doses and that consistent daily usage of rhodiola did not reduce the effects it had on exercise performance(8). Itís also been shown to be cardio protective through its neurotransmitter modulating effects and protective from different environmental stressors like extreme cold(15).

Training, or exercise in general, can be particularly fatiguing not just physically but also mentally. Itís important to keep the central nervous system functioning optimally during training for quality performance. Not only during training but also after, many of us canít afford to be run down for the rest of the day after training.

Thatís the primary function of Rhodiola Rosea in Origin, as an aid to help athletes cope with the mentally fatiguing effects of exercise both during and after training.
Rhodiola Rosea Overview:

Adaptogen helping the body cope with strenuous exercise
Enhance cognitive function
Improve mood and energy levels
Cardio protective

Di-caffeine malate

This relatively new form of caffeine has made its way into the supplement world already and is sold widely in diet pills and colas claiming a few benefits to regular caffeine such as improved digestion. There really isnít much relevant research in that regard but anecdotal evidence suggests di-caffeine malate is much smoother in comparison to generic caffeine anhydrous.

Origin contains just about as much caffeine as most other preworkouts but due to using dicaffeine malate it should feel much smoother and less jittery for those who are not very tolerant to caffeine. By mass, dicaffeine malate is just under 75% caffeine so the 200mg dose/serving in Origin actually yields about 150mg of pure caffeine per serving.
Aside from that di-caffeine malate still has the same awesome studied ergogenic effects regular caffeine has to offer such as:

Improved exercise performance(11,12,13,14)
Increased fat loss through accelerated lipolysis(12)
Improved recovery from training(9)
Blunts the cortisol response to training, increases testosterone levels(10)
Improve blood flow and vasodilation during exercise(29)

Caffeine can actually increase the amount of blood flow during exercise as well. I know itís commonly reported to be a vasoconstrictor but during exercise skeletal muscle regions are less receptive to vasoconstriction due to greatly enhanced blood flow. Caffeine is also a known phosphodiesterase(PDE) inhibitor(29) which has many effects at the cellular level one of which is vasodilation. A better-known PDE inhibitor would be Viagra, which effectively much more potent than caffeine in this regard but the principles are the same(30).

Overall, caffeine is likely one of the most underrated ergogenic considering the heaping amounts of supportive evidence and its relative cost to some of the more exotic ingredients out there. When used properly in moderation along with a proper exercise routine and diet it can have profound effects on your progress.
Theanine

This amino acid is very prominent in most teas and is considered the main pharmacological constituent responsible for the relaxing effect of teas. It does this by adjusting the frequency of certain brain waves, specifically scaling the brain towards the more focus attention derived alpha waves(17,18).

Whatís so special about alpha waves? Alpha waves are one of the four main brain waves(delta, theta, alpha, beta) and are acutely pronounced during relaxed focus and attention. Unfortunately a majority of us spend a lot of our time in the anxiety prone beta wave zone due to the stresses of daily life. Beta waves arenít very conducive to solid focus and as an athlete you know focus is incredibly important during competition. Theanine can relax you before the big competition, without putting you to sleep(23), so that your level of focus alone will intimidate the competition.

Theanineís ability to stimulate alpha waves is incredibly helpful in enhancing your workout cognition and many studies have gone to observe these effects alongside caffeine as well. The two play off each other in an incredibly effective synergistic fashion resulting in greatly improved memory, reaction time, and self-reported levels of mental fatigue(16). Theanine effectively blunts the Ďjittersí many experience from caffeine in larger doses while caffeine brings the overall energy state much higher.

Theanine has been studied in rodents using some exercise models to determine if it has anti-depressant qualities. If the animals work longer under stressful conditions but remain relatively similar in normal conditions than its considered to be anti-depressant, caffeine for example would be considered a strong anti-depressant(20). Theanine was found to have significant anti-depressant effects(21) and should result in greatly improved exercise tolerance and reduce the perceived level of fatigue in athletes using it.

On top of all that awesome stuff thereís more good news. If youíre a serious athlete and overtraining is more or less just something you do, theanine is going to be amazing for you. It is very common for athletes to feel lethargic and simply mentally drained after a taxing workout and this can be a pain if youíve got a mentally demanding job. Theanine has been studied in athletes at a dose of only 50mg to greatly accelerate mental recovery after exercise(22). This alongside Rhodiola should greatly attenuate any post exercise mental fatigue, letting you go on with the rest of your daily schedule on time and on point.
Theanine Overview:

Increase focus and relaxed attention
Smooth the energy from caffeine
Improve exercise tolerance and resistance to fatigue
Accelerate mental recovery from exercise

Origin Overview:

Origin will greatly accelerate your training because we made sure to use only the ingredients we would want in our own pre workout and only at doses that work. When you see the effects add up in your own training session we know youíll have a new favorite pre to cycle in.
Origin Total Mechanisms of Action:

Increase focus and relaxed attention
Improve exercise tolerance and resistance to fatigue
Accelerate mental recovery from exercise
Improved exercise performance
Increased fat loss through accelerated lipolysis
Improved recovery from training
Adaptogen helping the body cope with strenuous exercise
Enhance cognitive function
Improve mood and energy levels
Cardio protective
Increase GH, IGF-1 response to training
Reduce cortisol response to training
Improve body composition
Improve power output and quality of exercise performed
Increased blood flow leading to stronger pumps
Increased ammonia clearance from skeletal muscle
Reduces DOMS(Delayed Onset Muscle Soreness)
TAAR-1 agonist, enhanced vigilance

Origin FAQ:
When is the best time to take Origin?

We suggest 30-45 minutes before training for optimal dosing time but we also recommend trying your own dosing times and seeing what works best for you.
Can I stack Protocol Advanced and Origin?

Certainly, combining the two would have profound results on your training performance.
Is it best for weight training or can I take it for cardio?

Origin is built to enhance your performance regardless of whether itís a laps in the pool or reps in the weight room.
Iíve been using Origin for some time now and I think itís causing headaches?

This is actually a common side effect based on your individual tolerance to theanine. If this happens to you simply take time off and try and avoid teas and even some energy drinks that may contain theanine in higher doses. The dose used in Origin has been evaluated to be incredibly well tolerated and when caffeine is dosed alongside it, headaches are easily prevented.
References:

1. Hickner RC, Tanner CJ, Evans CA, Clark PD, Haddock A, Fortune C, Geddis H, Waugh W, McCammon M. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc. 2006 Apr;38(4):660-6. PubMed PMID: 16679980.

2. Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung. 1991 Jun;41(6):660-3. PubMed PMID: 1930358.

3. Pťrez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22. PubMed PMID: 20386132.

4. Eklund M, Bauer E, Wamatu J, Mosenthin R. Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev. 2005 Jun;18(1):31-48. PubMed PMID: 19079893.

5. Apicella JM, Lee EC, Bailey BL, Saenz C, Anderson JM, Craig SA, Kraemer WJ, Volek JS, Maresh CM. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. Eur J Appl Physiol. 2012 Sep 14. [Epub ahead of print] PubMed PMID: 22976217.

6. Hoffman JR, Ratamess NA, Kang J, Rashti SL, Faigenbaum AD. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009 Feb 27;6:7. PubMed PMID: 19250531; PubMed Central PMCID: PMC2651845.

7. Richard P, Brown MD, Patricia L, Gerbarg M, Ramazanov Z. Rhodiola rosea: A phytomedicinal overview. HerbalGram. 2002;56:40Ė52.

8. De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307. PubMed PMID: 15256690.

9. Pedersen DJ, Lessard SJ, Coffey VG, Churchley EG, Wootton AM, Ng T, Watt MJ, Hawley JA. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. J Appl Physiol. 2008 Jul;105(1):7-13. Epub 2008 May 8. PubMed PMID: 18467543.

10. Beaven CM, Hopkins WG, Hansen KT, Wood MR, Cronin JB, Lowe TE. Dose effect of caffeine on testosterone and cortisol responses to resistance exercise. Int J Sport Nutr Exerc Metab. 2008 Apr;18(2):131-41. PubMed PMID: 18458357.

11. Mohr M, Nielsen JJ, Bangsbo J. Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation. J Appl Physiol. 2011 Nov;111(5):1372-9. Epub 2011 Aug 11. PubMed PMID: 21836046.

12. Ryu S, Choi SK, Joung SS, Suh H, Cha YS, Lee S, Lim K. Caffeine as a lipolytic food component increases endurance performance in rats and athletes. J Nutr Sci Vitaminol (Tokyo). 2001 Apr;47(2):139-46. PubMed PMID: 11508705.

13. Anselme F, Collomp K, Mercier B, AhmaÔdi S, Prefaut C. Caffeine increases maximal anaerobic power and blood lactate concentration. Eur J Appl Physiol Occup Physiol. 1992;65(2):188-91. PubMed PMID: 1396643.

14. Graham TE, Spriet LL. Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. J Appl Physiol. 1995 Mar;78(3):867-74. PubMed PMID: 7775331.

15. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302. Review. PubMed PMID: 11410073.

16. Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008 Feb;77(2):113-22. Epub 2007 Sep 26. PubMed PMID: 18006208.

17. Gomez-Ramirez M, Higgins BA, Rycroft JA, Owen GN, Mahoney J, Shpaner M, Foxe
JJ. The deployment of intersensory selective attention: a high-density electrical mapping study of the effects of theanine. Clin Neuropharmacol. 2007 Jan-Feb;30(1):25-38. PubMed PMID: 17272967.

18. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its
effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PubMed PMID:
18296328.

19. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. Epub 2006 Aug 22. PubMed PMID: 16930802.

20. Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology (Berl). 2005 Jan;177(3):245-55. Epub 2004 Nov 18. Review. PubMed PMID: 15609067.

21. Yin C, Gou L, Liu Y, Yin X, Zhang L, Jia G, Zhuang X. Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice Phytother Res. 2011 Nov;25(11):1636-9. doi: 10.1002/ptr.3456. Epub 2011 Mar 21. PubMed PMID: 21425373.

22. Jšger, Ralf, Martin Purpura, Kurt-Reiner Geiss, Thorsten Barthel, Reinhard Schnittker, and Michael WeiŖ. "Improving Mental Regeneration after Physical Exercise." Journal of the International Society of Sports Nutrition 5.Suppl 1 (2008): P3. Print.

23. Mason, Russ. 200 Mg of Zen: L-Theanine Boosts Alpha Waves, Promotes Alert Relaxation. Alternative Complementary Therapies 7.2 (2001): 91-95. Print.

24. Rossato LG, Costa VM, Limberger RP, Bastos Mde L, Remi„o F. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 2011 Jan;49(1):8-16. Epub 2010 Nov 12. Review. PubMed PMID: 21075161.

25. Haller CA, Duan M, Jacob P 3rd, Benowitz N. Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. Br J Clin Pharmacol. 2008 Jun;65(6):833-40. Epub 2008 Mar 13. PubMed PMID: 18341680; PubMed Central PMCID: PMC2485232.

26. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005 May;26(5):274-81. Review. PubMed PMID: 15860375

27. Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol Psychiatry. 2012 May 29. doi: 10.1038/mp.2012.57. [Epub ahead of print] PubMed PMID: 22641180.

28. Womack CJ, Saunders MJ, Bechtel MK, Bolton DJ, Martin M, Luden ND, Dunham W, Hancock M. The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. J Int Soc Sports Nutr. 2012 Mar 15;9(1):7. PubMed PMID: 22420682; PubMed Central PMCID: PMC3334681.

29. Ribeiro JA, Sebasti„o AM. Caffeine and adenosine. J Alzheimers Dis. 2010;20 Suppl 1:S3-15. Review. PubMed PMID: 20164566.

30. Katz SD, Balidemaj K, Homma S, Wu H, Wang J, Maybaum S. Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol. 2000 Sep;36(3):845-51. PubMed PMID: 10987609.


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